Susceptibility to Disease.
نویسندگان
چکیده
منابع مشابه
KIR Gene Content Does Not Contribute to Susceptibility to Graves’ Disease
Background: Killer cell immunoglobulin-like receptors (KIR) are expressed on NK cells and a subset of T cells. The variable KIR receptors along with their ligands, HLA class I, influence risk for autoimmune and malignant diseases. Objective: To investigate the KIR gene profiles in relation to susceptibility to Graves’ disease in patients with ophthalmopathy. Methods: KIR genes profiles were ana...
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Genetic factors clearly cause Lewy-body Parkinson's disease (PD) in a subset of autosomal-dominant families. However, most cases of PD are sporadic. The two most likely models of four discussed for sporadic PD are the reduced penetrance model and the multifactorial model. Sporadic PD is likely to be caused by the combined effect of environmental precipitating factors and genetic susceptibility ...
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Animal cells possess thousands of long non-coding (lnc) RNAs, such as antisense noncoding RNA in the INK4 locus (ANRIL) , which have regulatory roles in the cells’ molecular mechanisms, including X-chromosome inactivation, and developmental processes. These lnc RNAs are known to influence the extensive spectrum of age-related disorders. Accordingly, there is evidence for the role of...
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One of the main problems in genetic epidemiology is to robustly predict genetic susceptibility to complex diseases based on the data from case/control studies. This becomes computationally challenging in presence of interactions between multiple genes. In order to efficiently search through enormous amount of possible combinations, it is necessary to apply heuristics and the greedy approach has...
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ژورنال
عنوان ژورنال: JAMA: The Journal of the American Medical Association
سال: 1904
ISSN: 0098-7484
DOI: 10.1001/jama.1904.02490530047013